Anti-ALKBH2 Polyclonal Antibody
Cat: K006863P
Summary:
| 【Product name】：Anti-ALKBH2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：121642 | 【Swiss Prot】：Q6NS38 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:500-2000. | |
| 【Immunogen】：Recombinant protein of human ALKBH2 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
Verified picture:
Western blot analysis with ALKBH2 antibody diluted at 1:1000;Lane:Human fetal liver, seminoma tissue, RAW264.7.