Anti-SETD2 Polyclonal Antibody
Cat: K006912P
Summary:
| 【Product name】：Anti-SETD2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：29072 | 【Swiss Prot】：Q9BYW2 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human SETD2 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Verified picture:
Immunohistochemistry of paraffin-embedded Human tonsil with SETD2 antibody diluted at 1:40