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Anti-CRK Polyclonal Antibody - Cy5.5
Cat: K007000P - Cy5.5
Summary:
【Product name】:Anti-CRK Polyclonal Antibody - Cy5.5 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:1398 【Swiss Prot】:P46108
【Tested applications】:FC ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of human CRK
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
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