Anti-PLEKHG6 Polyclonal Antibody
Cat: K007110P
Summary:
| 【Product name】：Anti-PLEKHG6 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：55200 | 【Swiss Prot】：Q3KR16 |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:500-2000. IHC 1:25-100. | |
| 【Immunogen】：Recombinant protein of human PLEKHG6 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Verified picture:
Western blot analysis with PLEKHG6 antibody diluted at 1:800; Lane: MDA-MB-231
Western blot analysis with SMAD4 antibody diluted at 1:500; Lane: SKOV3,HEPG2.