Anti-PTRH2 Polyclonal Antibody
Cat: K007153P
Summary:
| 【Product name】：Anti-PTRH2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：51651 | 【Swiss Prot】：Q9Y3E5 |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:10-100. | |
| 【Immunogen】：Recombinant protein of human PTRH2 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
PTRH2 (peptidyl-tRNA hydrolase 2), also known as BIT1 (Bcl-2 inhibitor of transcription 1), is a 179 amino acid mitochondrial protein. During apoptosis, PTRH2 is released from the mitochondia to the cytoplasm. Once in the cytoplasm, PTRH2 regulates the function of two transcriptional regulators, TLE5 and TLE1, thereby promoting caspase-independent cell death. It is also believed that the natural substrate for PTRH2 may be petidyl-tRNAs, which leave the ribosomes during protein synthesis.
Verified picture:
Western blot analysis with PTRH2 antibody diluted at 1:3000; Lane: Raji,Jurkat,HepG2,K-562
Immunohistochemistry of paraffin-embedded Human colorectal cancer with PTRH2 antibody diluted at 1:20