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Anti-DPM1 Polyclonal Antibody
Cat: K007257P
Summary:
【Product name】:Anti-DPM1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:8813 【Swiss Prot】:O60762
【Tested applications】:IHC
【Recommended dilution】:IHC 1:25-100.
【Immunogen】:Recombinant protein of human DPM1
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.
Verified picture:
Immunohistochemistry of paraffin-embedded Human thyroid cancer with DPM1 antibody diluted at 1:30