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Anti-CASR Polyclonal Antibody
Cat: K007286P
Summary:
【Product name】:Anti-CASR Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:846 【Swiss Prot】:P41180
【Tested applications】:IHC
【Recommended dilution】:IHC 1:25-100.
【Immunogen】:Recombinant protein of human CASR
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
Verified picture:
Immunohistochemistry of paraffin-embedded Human breast cancer with CASR antibody diluted at 1:30