Anti-Phospho-MLKL (S358) Polyclonal Antibody
Cat: K009418P
Summary:
| 【Product name】：Anti-Phospho-MLKL (S358) Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：197259 | 【Swiss Prot】：Q8NB16 |
| 【Tested applications】：IHC,WB | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-100. | |
| 【Immunogen】：A synthetic peptide of human Phospho-MLKL (S358) | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Swiss-Prot Acc.Q8NB16.Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Verified picture:
Western blot analysis with Phospho-MLKL (S358) antibody diluted at 1:1000;Lane: HT-29 HT-29 lysates treated with TNF alpha+ Smac mimetic+ zVAD.