Anti-PMAIP1 Polyclonal Antibody
Cat: K108337P
Summary:
| 【Product name】：Anti-PMAIP1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5366 | 【Swiss Prot】：Q13794 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human PMAIP1 | |
| 【Public Immunogen Range】：1-54aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with PMAIP1 antibody diluted at 1:100.