Anti-GPR52 Polyclonal Antibody - SAlexa Fluor 488
Cat: K108440P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-GPR52 Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9293 | 【Swiss Prot】：Q9Y2T5 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human GPR52 | |
| 【Public Immunogen Range】：200-250/361aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum. Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation.
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