Anti-Artemis (phospho Ser516) Polyclonal Antibody
Cat: K009394P
Summary:
| 【Product name】：Anti-Artemis (phospho Ser516) Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：64421 | 【Swiss Prot】：Q96SD1 |
| 【Tested applications】：ELISA,IHC,WB | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-100. ELISA 1:10000. | |
| 【Immunogen】：A synthetic peptide of human Artemis (phospho Ser516) | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by non homologous end joining.
Verified picture:
Western blot analysis with Artemis (phospho Ser516) antibody diluted at 1:1000;Lane: HepG2 cells.
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using Artemis (Phospho-Ser516) Antibody. The picture on the right is blocked with the phospho peptide.
Immunohistochemistry of paraffin-embedded Human lung carcinoma with Artemis (phospho Ser516) antibody diluted at 1:100.