Anti-BAX Monoclonal Antibody
Cat: K009432M
Summary:
| 【Product name】：Anti-BAX Monoclonal Antibody | 【Source】：Mouse |
| 【Isotype】：IgG2b | 【Purification】：Affinity purification |
| 【Gene ID】：581 | 【Swiss Prot】：Q07812 |
| 【Tested applications】：ELISA,FCM,IHC,WB | |
| 【Recommended dilution】：WB 1:5000-20000. IHC 1:500-2000. | |
| 【Immunogen】：Recombinant protein of human BAX | |
| 【Public Immunogen Range】：1-192aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction. BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria. The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis.
Verified picture:
Immunohistochemistry of paraffin-embedded Human liver cancer with BAX antibody diluted at 1:1000
Western blot analysis with BAX antibody diluted at 1:15000;Lane: HeLa HEK-293 COLO 320 PC-12 ROS1728 Neuro-2a.