Anti-BAX Monoclonal Antibody - SAlexa Fluor 555
Cat: K009432M - SAlexa Fluor 555
Summary:
| 【Product name】：Anti-BAX Monoclonal Antibody - SAlexa Fluor 555 | 【Source】：Mouse |
| 【Isotype】：IgG2b | 【Purification】：Affinity purification |
| 【Gene ID】：581 | 【Swiss Prot】：Q07812 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human BAX | |
| 【Public Immunogen Range】：1-192aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction. BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria. The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis.
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