Anti-TCF7 Polyclonal Antibody - SAlexa Fluor 594
Cat: K108542P - SAlexa Fluor 594
Summary:
| 【Product name】：Anti-TCF7 Polyclonal Antibody - SAlexa Fluor 594 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6932 | 【Swiss Prot】：P36402 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of Human TCF7 | |
| 【Public Immunogen Range】：80-130/384aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ CD8+ immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
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