Anti-FADD Polyclonal Antibody
Cat: K000401P
Summary:
| 【Product name】：Anti-FADD Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8772 | 【Swiss Prot】：Q13158 |
| 【Tested applications】：WB,IP | |
| 【Recommended dilution】：WB 1:500-2000. IP 0.5μg-4μg. | |
| 【Immunogen】：Recombinant protein of human FADD | |
| 【Public Immunogen Range】：1-208aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Verified picture:
Immunohistochemistry of paraffin-embedded Rat kidney with FADD antibody diluted at 1:100
Western blot analysis with FADD antibody diluted at 1:1000;Lane: 293T MCF7 HeLa Mouse liver Mouse kidney Mouse heart.