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Anti-CASP1 Polyclonal Antibody
Cat: K001773P
Summary:
【Product name】:Anti-CASP1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:834 【Swiss Prot】:P29466
【Tested applications】:WB,IF
【Recommended dilution】:WB 1:1000-5000.IF 1:50-200.
【Immunogen】:A synthetic peptide of human CASP1
【Public Immunogen Range】:201-300aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colon with CASP1 antibody diluted at 1:100
Immunofluorescence analysis of C6 cells using CASP1 antibody at dilution of 1:100 (40x lens).
Immunofluorescence analysis of Raw264.7 cells using CASP1 antibody diluted at 1:100.