Anti-RB1 Polyclonal Antibody - Cy7
Cat: K003230P - Cy7
Summary:
| 【Product name】：Anti-RB1 Polyclonal Antibody - Cy7 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5925 | 【Swiss Prot】：P06400 |
| 【Tested applications】：WB,IF | |
| 【Recommended dilution】：WB 1:500-2000.IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human RB | |
| 【Public Immunogen Range】：830-928aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
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