Anti-SORD Polyclonal Antibody
Cat: K003232P
Summary:
| 【Product name】：Anti-SORD Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：6652 | 【Swiss Prot】：Q00796 |
| 【Tested applications】：IF,IHC,WB | |
| 【Recommended dilution】：WB 1:500-1000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human SORD | |
| 【Public Immunogen Range】：145-300aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.
Verified picture:
Western blot analysis with SORD antibody diluted at 1:1000;Lane: HeLa HT-29 HepG2.
Immunohistochemistry of paraffin-embedded pancreatic cancer(hu) using Anti-SORD Rabbit Polyclonal Antibody at dilution of 1:100 (x100 lens��x200 lens).
Immunohistochemistry of paraffin-embedded mouse kidney with SORD antibody diluted at 1:100.
Immunofluorescence analysis of Huh7 cells using SORD antibody diluted at 1:100.