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Anti-RAMP1 Polyclonal Antibody
Cat: K004536P
Summary:
【Product name】:Anti-RAMP1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:10267 【Swiss Prot】:O60894
【Tested applications】:IF,WB
【Recommended dilution】:WB 1:100-500. IF 1:50-200.
【Immunogen】:A synthetic peptide of human RAMP1
【Public Immunogen Range】:21-120aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms.
Verified picture:
Western blot analysis with RAMP1 antibody diluted at 1:1000;Lane: Mouse brain.
Immunofluorescence analysis of NIH3T3 cells using RAMP1 antibody diluted at 1:100.