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Anti-TDG Polyclonal Antibody - FITC
Cat: K108892P - FITC
Summary:
【Product name】:Anti-TDG Polyclonal Antibody - FITC 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:6996 【Swiss Prot】:Q13569
【Tested applications】:ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of Human TDG
【Public Immunogen Range】:225-275/410aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
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