Anti-CYBB Polyclonal Antibody
Cat: K108996P
Summary:
| 【Product name】：Anti-CYBB Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1536 | 【Swiss Prot】：P04839 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：A synthetic peptide of human CYBB | |
| 【Public Immunogen Range】：490-540/570aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Verified picture:
Western blot analysis with CYBB antibody diluted at 1:2000;Lane:Mouse brain,Rat brain