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Anti-MSN Polyclonal Antibody
Cat: K109008P
Summary:
【Product name】:Anti-MSN Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:4478 【Swiss Prot】:P26038
【Tested applications】:IF,IHC,WB
【Recommended dilution】:WB 1:8000-12000. IHC 1:100-300. IF 1:50-200.
【Immunogen】:A synthetic peptide of human MSN
【Public Immunogen Range】:455-505/577aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs. Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation.
Verified picture:
Immunohistochemistry of paraffin-embedded Human breast cancer with MSN antibody diluted at 1:200
Immunofluorescence analysis of HepG2 cells using MSN antibody diluted at 1:100
Western blot analysis with MSN antibody diluted at 1:8000;Lane: Jurkat,Hela,HMC1,A431,HEK293,Vero,HT29,Raji,NIH3T3,SH-SY5Y,Mouse thymus,Mouse kidney