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Anti-CBX2 Polyclonal Antibody
Cat: K109029P
Summary:
【Product name】:Anti-CBX2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:84733 【Swiss Prot】:Q14781
【Tested applications】:IHC
【Recommended dilution】:IHC 1:100-300.
【Immunogen】:Recombinant protein of human CBX2
【Public Immunogen Range】:1-212aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) . Plays a role in the lineage differentiation of the germ layers in embryonic development. Involved in sexual development, acting as activator of NR5A1 expression.
Verified picture:
Immunohistochemistry of paraffin-embedded Human prostate cancer with CBX2 antibody diluted at 1:200