Anti-MMP2 Monoclonal Antibody
Cat: K200085M
Summary:
| 【Product name】：Anti-MMP2 Monoclonal Antibody | 【Source】：Mouse |
| 【Isotype】：IgG1 | 【Purification】：Affinity purification |
| 【Gene ID】：4313 | 【Swiss Prot】：P08253 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：Synthetic Peptide | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
MMP2, also named as CLG4A, Gelatinase Am, TBE-1 and PEX, belongs to the peptidase M10A family. It is ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. MMP2 contributes to myocardial oxidative stress by regulating the activity of GSK3beta. It cleaves GSK3beta in vitro. MMP2 can be cleaved into PEX chain(~60kd). Western blot analysis showed that the 72 kDa and 62/65 kDa proteinase activities were pro-MMP2 and the active enzyme, respectively (PMID:11112697,PMID: 30867536).
Verified picture:
Immunohistochemistry of paraffin-embedded Human prostate cancer with MMP2 antibody diluted at 1:200
Immunohistochemistry of paraffin-embedded Human stomach cancer with MMP2 antibody diluted at 1:200