下载
Anti-UBR1 Polyclonal Antibody
Cat: K109222P
Summary:
【Product name】:Anti-UBR1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:197131 【Swiss Prot】:Q8IWV7
【Tested applications】:IHC
【Recommended dilution】:IHC 1:25-100.
【Immunogen】:A synthetic peptide of human UBR1
【Public Immunogen Range】:1665-1715/1749aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Verified picture:
Immunohistochemistry of paraffin-embedded Human endometrial cancer with UBR1 antibody diluted at 1:40