Anti-ZNF598 Polyclonal Antibody
Cat: K109259P
Summary:
| 【Product name】：Anti-ZNF598 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：90850 | 【Swiss Prot】：Q86UK7 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human ZNF598 | |
| 【Public Immunogen Range】：270-320/904aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.
Verified picture:
Immunohistochemistry of paraffin-embedded
Human stomach cancer with ZNF598 antibody diluted at 1:100