Anti-ITM2B Polyclonal Antibody - FITC
Cat: K109438P - FITC
Summary:
| 【Product name】：Anti-ITM2B Polyclonal Antibody - FITC | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9445 | 【Swiss Prot】：Q9Y287 |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human ITM2B | |
| 【Public Immunogen Range】：130-180/266aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.
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