Anti-KMO Polyclonal Antibody
Cat: K109483P
Summary:
| 【Product name】：Anti-KMO Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8564 | 【Swiss Prot】：O15229 |
| 【Tested applications】：WB,IHC,ELISA | |
| 【Recommended dilution】：WB 1:8000-12000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human KMO | |
| 【Public Immunogen Range】：1-407aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.
Verified picture:
Immunohistochemistry of paraffin-embedded Rat heart with KMO antibody diluted at 1:100
Western blot analysis with KMO antibody diluted at 1:10000;Lane: Hela