Anti-HORMAD2 Polyclonal Antibody - SAlexa Fluor 750
Cat: K109554P - SAlexa Fluor 750
Summary:
| 【Product name】：Anti-HORMAD2 Polyclonal Antibody - SAlexa Fluor 750 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：150280 | 【Swiss Prot】：Q8N7B1 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human HORMAD2 | |
| 【Public Immunogen Range】：1-308aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity).
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