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Anti-FZD2 Polyclonal Antibody - SAlexa Fluor 660
Cat: K109739P - SAlexa Fluor 660
Summary:
【Product name】:Anti-FZD2 Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:2535 【Swiss Prot】:Q14332
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-3000. IHC 1:50-200.
【Immunogen】:A synthetic peptide of Human FZD2
【Public Immunogen Range】:15-65/565aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:25759469). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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