Anti-FZD7 Polyclonal Antibody - SAlexa Fluor 660
Cat: K109740P - SAlexa Fluor 660
Summary:
| 【Product name】：Anti-FZD7 Polyclonal Antibody - SAlexa Fluor 660 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8324 | 【Swiss Prot】：O75084 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of Human FZD7 | |
| 【Public Immunogen Range】：10-60/574aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
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