Anti-BAG3 Polyclonal Antibody - SAlexa Fluor 680
Cat: K109755P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-BAG3 Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：9531 | 【Swiss Prot】：O95817 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of Human BAG3 | |
| 【Public Immunogen Range】：1-576aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
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