Anti-PTPN11 Polyclonal Antibody
Cat: K109833P
Summary:
| 【Product name】：Anti-PTPN11 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：5781 | 【Swiss Prot】：Q06124 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human PTPN11 | |
| 【Public Immunogen Range】：505-555/597aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with PTPN11 antibody diluted at 1:100
Immunohistochemistry of paraffin-embedded Human endometrial cancer with PTPN11 antibody diluted at 1:100