Anti-RHOH Polyclonal Antibody
Cat: K109928P
Summary:
| 【Product name】：Anti-RHOH Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：399 | 【Swiss Prot】：Q15669 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide ofHuman RHOH | |
| 【Public Immunogen Range】：10-60/194aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein.
Verified picture:
Western blot analysis with RHOH antibody diluted at 1:2000;Lane: Jurkat,HT29,Mouse thymus
Immunohistochemistry of paraffin-embedded Human colorectal cancer with RHOH antibody diluted at 1:100