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Anti-CBX6 Polyclonal Antibody - SAlexa Fluor 405
Cat: K109939P - SAlexa Fluor 405
Summary:
【Product name】:Anti-CBX6 Polyclonal Antibody - SAlexa Fluor 405 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:23466 【Swiss Prot】:O95503
【Tested applications】:WB
【Recommended dilution】:WB 1:1000-3000.
【Immunogen】:A synthetic peptide ofHuman CBX6
【Public Immunogen Range】:335-385/412aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (PubMed:18927235). Recruitment to chromatin might occur in an H3K27me3-independent fashion (By similarity). May have a PRC1-independent function in embryonic stem cells (By similarity).
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