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Anti-SUV39H2 Polyclonal Antibody - FITC
Cat: K110018P - FITC
Summary:
【Product name】:Anti-SUV39H2 Polyclonal Antibody - FITC 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:79723 【Swiss Prot】:Q9H5I1
【Tested applications】:ICC IF
【Recommended dilution】:Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200
【Immunogen】:Recombinant protein of Human SUV39H2
【Public Immunogen Range】:1-350aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin
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