Anti-IFT57 Polyclonal Antibody - Cy3.5
Cat: K110258P - Cy3.5
Summary:
| 【Product name】：Anti-IFT57 Polyclonal Antibody - Cy3.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：55081 | 【Swiss Prot】：Q9NWB7 |
| 【Tested applications】：IF,IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human IFT57 | |
| 【Public Immunogen Range】：140-190/429aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
Verified picture: