Anti-CNOT2 Polyclonal Antibody
Cat: K110459P
Summary:
| 【Product name】：Anti-CNOT2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4848 | 【Swiss Prot】：Q9NZN8 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human CNOT2 | |
| 【Public Immunogen Range】：380-430/540aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer using CNOT2 antibody diluted at 1:100
Western blot analysis with CNOT2 antibody diluted at 1:2000;Lane:HeLa,A549,MCF7,HT29