Anti-MRTFA Polyclonal Antibody
Cat: K110461P
Summary:
| 【Product name】：Anti-MRTFA Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：57591 | 【Swiss Prot】：Q969V6 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:1000-3000. | |
| 【Immunogen】：A synthetic peptide of human MRTFA | |
| 【Public Immunogen Range】：755-805/931aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.
Verified picture:
Western blot analysis with MRTFA antibody diluted at 1:2000;Lane:COL-O205,HeLa,HL60,NIH3T3,HEK293,HepG2,HT29,K-562,293T,Mouse lung