Anti-MRTFA Polyclonal Antibody - SAlexa Fluor 488
Cat: K110461P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-MRTFA Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：57591 | 【Swiss Prot】：Q969V6 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human MRTFA | |
| 【Public Immunogen Range】：755-805/931aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus.
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