Anti-NOLC1 Polyclonal Antibody
Cat: K110471P
Summary:
| 【Product name】：Anti-NOLC1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：9221 | 【Swiss Prot】：Q14978 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:2000-5000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human NOLC1 | |
| 【Public Immunogen Range】：610-660/699aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).
Verified picture:
Immunohistochemistry of paraffin-embedded Human stomach cancer using NOLC1 antibody diluted at 1:80
Western blot analysis with NOLC1 antibody diluted at 1:3000;Lane:K-562,HeLa,Jurkat,HEK293,HL-60