Anti-PTBP1 Polyclonal Antibody - SAlexa Fluor 647
Cat: K110480P - SAlexa Fluor 647
Summary:
| 【Product name】：Anti-PTBP1 Polyclonal Antibody - SAlexa Fluor 647 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Octanoic acid-ammonium sulfate precipitation |
| 【Gene ID】：5725 | 【Swiss Prot】：P26599 |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human PTBP1 | |
| 【Public Immunogen Range】：380-430/531aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).
Verified picture: