Anti-WDR41 Polyclonal Antibody
Cat: K110527P
Summary:
| 【Product name】：Anti-WDR41 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：55255 | 【Swiss Prot】：Q9HAD4 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human WDR41 | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity.
Verified picture:
Western blot analysis with WDR41 antibody diluted at 1:2000;Lane:THP-1,SH-SY5Y,Rat testis,HEK293
Immunohistochemistry of paraffin-embedded Human colorectal cancer using WDR41 antibody diluted at 1:100
Immunohistochemistry of paraffin-embedded Human liver cancer using WDR41 antibody diluted at 1:100