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Anti-BLOC1S2 Polyclonal Antibody - SAlexa Fluor 532
Cat: K110603P - SAlexa Fluor 532
Summary:
【Product name】:Anti-BLOC1S2 Polyclonal Antibody - SAlexa Fluor 532 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:282991 【Swiss Prot】:Q6QNY1
【Tested applications】:IHC
【Recommended dilution】:IHC 1:50-200.
【Immunogen】:Recombinant protein of human BLOC1S2
【Public Immunogen Range】:1-99aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421).
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