RSPRY1 is a 576 amino acid secreted protein that contains one RING-type zinc finger and a B30.2/SPRY domain. Existing as two alternatively spliced isoforms, RSPRY1 is encoded by a gene that maps to human chromosome 16q13. Chromosome 16 encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.