Anti-GNL3L Polyclonal Antibody - SAlexa Fluor 532
Cat: K110672P - SAlexa Fluor 532
Summary:
| 【Product name】：Anti-GNL3L Polyclonal Antibody - SAlexa Fluor 532 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：54552 | 【Swiss Prot】：Q9NVN8 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human GNL3L | |
| 【Public Immunogen Range】：1-51/582aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Verified picture: