Anti-JUP Polyclonal Antibody
Cat: K110725P
Summary:
| 【Product name】：Anti-JUP Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3728 | 【Swiss Prot】：P14923 |
| 【Tested applications】：ELISA,IHC,WB | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human JUP | |
| 【Public Immunogen Range】：396-746aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Verified picture:
Western blot analysis with JUP antibody diluted at 1:2000;Lane:A431,HeLa,T47D,MCF7,Mouse heart
Immunohistochemistry of paraffin-embedded Human colorectal cancer with JUP antibody diluted at 1:100
Immunohistochemistry of paraffin-embedded Human endometrial cancer with JUP antibody diluted at 1:100