Anti-NOTCH2(Cleaved-Ala1734) Polyclonal Antibody
Cat: K110834P
Summary:
| 【Product name】：Anti-NOTCH2(Cleaved-Ala1734) Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4853 | 【Swiss Prot】：Q04721 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human NOTCH2(Cleaved-Ala1734) | |
| 【Public Immunogen Range】：1695-1745/2471aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593). Positively regulates self-renewal of liver cancer cells (PubMed:25985737).
Verified picture:
Immunohistochemistry of paraffin-embedded Human endometrial cancer with NOTCH2(Cleaved-Ala1734) antibody diluted at 1:100