Anti-MCM7 Polyclonal Antibody
Cat: K110919P
Summary:
| 【Product name】：Anti-MCM7 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4176 | 【Swiss Prot】：P33993 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. | |
| 【Immunogen】：Recombinant protein of human MCM7 | |
| 【Public Immunogen Range】：1-350aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage.
Verified picture:
Western blot analysis with MCM7 antibody diluted at 1:2000;Lane: MCF7,293T,K-562,Jurkat.
Immunohistochemistry of paraffin-embedded Human stomach cancer with MCM7 antibody diluted at 1:200.