Anti-MDM2 Polyclonal Antibody
Cat: K009938P
Summary:
| 【Product name】：Anti-MDM2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：4193 | 【Swiss Prot】：Q00987 |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:500-1000. | |
| 【Immunogen】：Recombinant protein of human MDM2. | |
| 【Public Immunogen Range】：200-430aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Verified picture:
Western blot analysis with MDM2 antibody diluted at 1:1000;Lane: C2C12.
Immunofluorescence analysis of C6 cells using MDM2 antibody diluted at 1:100.